Suppressive effect of strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice.

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dc.contributor.authorDuddukuri, Govinda Raoen_US
dc.contributor.authorBrahmam, A Nagaen_US
dc.contributor.authorRao, D Nen_US
dc.date.accessioned2008-10-17en_US
dc.date.accessioned2009-05-27T09:37:47Z
dc.date.available2008-10-17en_US
dc.date.available2009-05-27T09:37:47Z
dc.date.issued2008-10-17en_US
dc.description.abstractStrychnos nux-vomica Linn. (SNV; Loganiaceae), a medicinal plant has been used as folk medicine for alleviating inflammation, joint pains and allergic symptoms. In the present study, we examined its possible immunomodulatory effect on induction of ovalbumin (OVA)-specific IgE antibody response in a murine model, as evaluated by passive cutaneous anaphylaxis (PCA). The OVA-specific IgE antibody response was significantly suppressed in BALB/c mice (H-2d), following intraperitoneal administration of aqueous stem extract of the plant along with OVA. Furthermore, the different doses of SNV extract were found to significantly suppress the induction of OVA-specific IgE antibody response. The anti-OVA IgE antibody response was suppressed in different haplotypes of mice viz., C57BL/6 (H-2b) and SWR/J (H-29). However, preliminary findings revealed no significant change in the total IgG antibody response against OVA, as evaluated by ELISA. These results confirm the suppressive activity of S. nux-vomica on allergen-specific IgE antibody response and suggest its possible application in allergic conditions. Keywords: Strychnlos nux-vomica, Immunomodulation, Immunosuppression, IgE antibody response, Passive cutaneous anaphylaxis, ELISAen_US
dc.description.affiliationDepartment of Biochemistry, GITAM University, Visakhapatnam 530 045, Andhra Pradesh, India. dgrao@rediffmail.comen_US
dc.identifier.citationDuddukuri GR, Brahmam AN, Rao DN. Suppressive effect of strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice. Indian Journal of Biochemistry & Biophysics. 2008 Oct; 45(5): 341-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28083
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshImmunoglobulin E --biosynthesisen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshOvalbumin --immunologyen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshStrychnos nux-vomica --chemistryen_US
dc.titleSuppressive effect of strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice.en_US
dc.typeJournal Articleen_US
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