Mode of action of iron on arylsulphatases under acute lead acetate treated conditions in rats.

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dc.contributor.authorSantra, Men_US
dc.contributor.authorBasu, Aen_US
dc.contributor.authorChatterjee, G Cen_US
dc.date.accessioned1989-04-01en_US
dc.date.accessioned2009-05-27T09:26:27Z
dc.date.available1989-04-01en_US
dc.date.available2009-05-27T09:26:27Z
dc.date.issued1989-04-01en_US
dc.description.abstractArylsulphatases A, B and C were found to be inhibited in liver and kidney tissues under lead acetate-treated conditions (both in vivo and in vitro) in rats. When lead acetate-treated animals (in vivo) were supplemented with ferric ammonium citrate (in vivo), a remarkable recovery was found in the activities of all arylsulphatases A, B and C whereas ferric ammonium citrate itself had no effect on the activities of arylsulphatases. When both the in vivo and in vitro lead acetate-treated arylsulphatases were supplemented with the purified ferritins (in vitro) it was observed that lead-induced inhibition of the activities of arylsulphatases was successfully reversed. It was also found that ferritins were able to bind a large quantity of lead. These results indicated that ferritins were directly involved for reactivation of arylsulphatases which were inhibited by lead. It was well established that a response to iron administration in rats was an immediate de novo stimulation of ferritin biosynthesis. Iron might therefore protect the enzymatic activities of arylsulphatases by enhancing the level of ferritin in liver and kidney tissues which is known to bind a large quantity of lead thereby ameliorating their toxic effects in the living system.en_US
dc.identifier.citationSantra M, Basu A, Chatterjee GC. Mode of action of iron on arylsulphatases under acute lead acetate treated conditions in rats. Indian Journal of Biochemistry & Biophysics. 1989 Apr; 26(2): 92-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27514
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArylsulfatases --metabolismen_US
dc.subject.meshIron --physiologyen_US
dc.subject.meshKidney --drug effectsen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshOrganometallic Compounds --toxicityen_US
dc.subject.meshRatsen_US
dc.subject.meshSulfatases --metabolismen_US
dc.titleMode of action of iron on arylsulphatases under acute lead acetate treated conditions in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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