Chronic myelogenous leukemia: alterations in red cell membrane band 3 and increased IgG binding.

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dc.contributor.authorKundu, Men_US
dc.contributor.authorBasu, Jen_US
dc.contributor.authorChakrabarti, Pen_US
dc.date.accessioned1990-12-01en_US
dc.date.accessioned2009-05-27T09:14:45Z
dc.date.available1990-12-01en_US
dc.date.available2009-05-27T09:14:45Z
dc.date.issued1990-12-01en_US
dc.description.abstractChronic myelogenous leukemia (CML) is a hematologic malignancy arising from an abnormal hemopoietic stem cell. Our earlier studies have identified defects in spectrin tetramer formation and organization of cytoskeletal proteins (Basu et al., Biochim. Biophys. Acta 1988, 121-126); and decreased ankyrin binding to ankyrin-depleted vesicles in CML patients. These may lead to clustering of band 3 and increased binding of autologous IgG. This has now been explored by studying the binding of 125I-protein A to normal and CML erythrocytes. There is increased binding of 125I-protein A in CML erythrocytes compared to normal erythrocytes. Since binding of autologous IgG is responsible for removal of erythrocytes from the circulation, the above findings suggest that CML erythrocytes are likely to be prematurely removed from the circulation, accounting for anemia.en_US
dc.description.affiliationDepartment of Chemistry, Bose Institute, Calcutta.en_US
dc.identifier.citationKundu M, Basu J, Chakrabarti P. Chronic myelogenous leukemia: alterations in red cell membrane band 3 and increased IgG binding. Indian Journal of Biochemistry & Biophysics. 1990 Dec; 27(6): 456-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26915
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.mesh4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Aciden_US
dc.subject.mesh4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid --analogs & derivativesen_US
dc.subject.meshAnion Exchange Protein 1, Erythrocyte --chemistryen_US
dc.subject.meshAnkyrinsen_US
dc.subject.meshBlood Proteins --metabolismen_US
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_US
dc.subject.meshErythrocyte Membrane --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin G --metabolismen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive --blooden_US
dc.subject.meshMembrane Proteins --metabolismen_US
dc.subject.meshStaphylococcal Protein A --metabolismen_US
dc.subject.meshSulfates --metabolismen_US
dc.titleChronic myelogenous leukemia: alterations in red cell membrane band 3 and increased IgG binding.en_US
dc.typeJournal Articleen_US
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