Impact of protein deficiency and exposure to hexachlorocyclohexane or malathion on lipid metabolism in pregnant rats.

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dc.contributor.authorPrabhakaran, Sen_US
dc.contributor.authorDevi, K Sen_US
dc.date.accessioned1993-08-01en_US
dc.date.accessioned2009-05-27T09:44:27Z
dc.date.available1993-08-01en_US
dc.date.available2009-05-27T09:44:27Z
dc.date.issued1993-08-01en_US
dc.description.abstractDietary intake of three oral doses of hexachlorocyclohexane (HCH) (60 mg/kg body wt) or malathion (500 mg/kg) by normal and protein-deficient diet fed pregnant rats on the 6th, 10th and 14th day of gestation resulted in the impairment of lipid metabolism, viz. hypercholesterolemia and hypertriglyceridemia. The cholesterol, triglyceride and phospholipid contents in serum, brain, liver, kidney and uterus were increased significantly by HCH and malathion exposure, irrespective of the protein content in the diet. The incorporation of [1,2-14C]acetate into the hepatic lipids was stimulated by both HCH and malathion, suggesting a higher rate of lipid synthesis in the liver of normal and protein-deficient diet fed dams. The low protein content in the diet intensified the pesticide-induced changes and more severe alterations were noticed in HCH exposed dams than in malathion exposed dams.en_US
dc.description.affiliationDepartment of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram.en_US
dc.identifier.citationPrabhakaran S, Devi KS. Impact of protein deficiency and exposure to hexachlorocyclohexane or malathion on lipid metabolism in pregnant rats. Indian Journal of Biochemistry & Biophysics. 1993 Aug; 30(4): 234-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28420
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholesterol --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucosephosphate Dehydrogenase --metabolismen_US
dc.subject.meshHydroxymethylglutaryl CoA Reductases --metabolismen_US
dc.subject.meshKidney --drug effectsen_US
dc.subject.meshLindane --toxicityen_US
dc.subject.meshLipid Metabolismen_US
dc.subject.meshLipolysis --drug effectsen_US
dc.subject.meshLipoprotein Lipase --metabolismen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshMalate Dehydrogenase --metabolismen_US
dc.subject.meshMalathion --toxicityen_US
dc.subject.meshPhospholipids --metabolismen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications --metabolismen_US
dc.subject.meshPregnancy, Animal --metabolismen_US
dc.subject.meshProtein-Energy Malnutrition --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTriglycerides --metabolismen_US
dc.titleImpact of protein deficiency and exposure to hexachlorocyclohexane or malathion on lipid metabolism in pregnant rats.en_US
dc.typeJournal Articleen_US
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