Nephroprotective Effects of Vernonia amygdalina in Alloxan-induced Diabetes in Rats

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dc.contributor.authorAdeoye, Adegbolagun T.en_US
dc.contributor.authorAdemola, A. Oyagbemien_US
dc.contributor.authorTemidayo, O. Omobowaleen_US
dc.contributor.authorAduragbenro, D. Adedapoen_US
dc.contributor.authorAbiodun, E. Ayodeleen_US
dc.contributor.authorMomoh, A. Yakubuen_US
dc.contributor.authorAdeolu, A. Adedapoen_US
dc.date.accessioned2020-05-05T07:03:51Z
dc.date.available2020-05-05T07:03:51Z
dc.date.issued2018-03
dc.description.abstractBackground: Diabetic nephropathy is a leading cause of end-stage renal failure worldwide. Purpose: The methanol leaf extract of Vernonia amygdalina (MLVA) was thus investigated for its nephroprotective effects in diabetes.Materials and Methods: Diabetes was induced in male Wistar rats by a single intraperitoneal (I.P) injection of a freshly prepared solution of Alloxan monohydrate (100 mg/kg). Forty-eight hours after alloxan administration, rats with fasting blood glucose levels of 200 mg/dl and above were used for the study. Animals were grouped into five (A-E) of nine animals each. Group A was non-diabetic non treated control; Group B animals were the diabetic untreated control rats while groups C, D and E animals were diabetic and treated with glibenclamide, MLVA 200 mg/kg and MVLA 400 mg/kg respectively. Biochemical changes were evaluated by measuring the serum markers of kidney damage (creatinine and blood urea nitrogen). Markers of oxidative stress and antioxidant activities were measured in renal tissues. Histopathological and immunohistochemical changes were also evaluated.Results: Four-week administration of MLVA produced significant (p<0.05) decrease in serum creatinine, urea, and oxidative markers but it caused a significant increase in enzymic and nonenzymic antioxidant as well as downregulation of Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) and upregulation of B-cell lymphoma 2 (Bcl-2).Conclusion: MLVA ameliorates diabetic nephropathy through its antioxidant, anti-inflammatory and antiapoptotic effectsen_US
dc.identifier.affiliationsDepartment of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Nigeriaen_US
dc.identifier.affiliationsDepartment of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeriaen_US
dc.identifier.affiliationsDepartment of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeriaen_US
dc.identifier.affiliationsDepartment of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Nigeriaen_US
dc.identifier.affiliationsDepartment of Botany, Faculty of Science, University of Ibadan, Nigeriaen_US
dc.identifier.affiliationsDepartment of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, Texas Southern University, Houston, TX, USAen_US
dc.identifier.affiliationsDepartment of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Nigeriaen_US
dc.identifier.citationAdeoye Adegbolagun T., Ademola A. Oyagbemi, Temidayo O. Omobowale, Aduragbenro D. Adedapo, Abiodun E. Ayodele, Momoh A. Yakubu, Adeolu A. Adedapo . Nephroprotective Effects of Vernonia amygdalina in Alloxan-induced Diabetes in Rats . International Journal of Biochemistry Research & Review. 2018 Mar; 21(1): 1-15en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200623
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume21en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2018/40100en_US
dc.subjectVernonia amygdalinaen_US
dc.subjectnephroprotectionen_US
dc.subjectanti-oxidantsen_US
dc.subjectanti-inflammatoryen_US
dc.subjectBcl-2en_US
dc.subjectNF-?Ben_US
dc.titleNephroprotective Effects of Vernonia amygdalina in Alloxan-induced Diabetes in Ratsen_US
dc.typeJournal Articleen_US
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