Liposomal hamycin in the control of experimental aspergillosis in mice: relative toxicity, therapeutic efficacy and tissue distribution of free and liposomal hamycin.

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dc.contributor.authorMoonis, Men_US
dc.contributor.authorAhmad, Ien_US
dc.contributor.authorBachhawat, B Ken_US
dc.date.accessioned1992-08-01en_US
dc.date.accessioned2009-05-27T09:43:30Z
dc.date.available1992-08-01en_US
dc.date.available2009-05-27T09:43:30Z
dc.date.issued1992-08-01en_US
dc.description.abstractTherapeutic efficacy of liposomal Hamycin has been evaluated in an animal model system for aspergillosis in Balb/c mice. Hamycin was intercalated into soya phosphatidyl choline (SPC), SPC: choline (1:1, vol./vol.) and DMPC liposomes. A single dose of either 0.1 mg/kg, 0.25 mg/kg or 0.5 mg/kg of liposomal Hamycin and 0.1 mg/kg of free Hamycin was injected (i.v.) into animals infected with Aspergillus fumigatus. An increase in the survival rate of animals along with decrease in fungal count in various organs was observed with liposomal administration. Incorporation of cholesterol into liposomes decreased the in vivo toxicity of Hamycin in a dose dependent manner. However, antifungal activity both in the presence and absence of cholesterol showed marked variation as compared to that of non-aromatic polyenes, e.g. amphotericin B. Analysis of Hamycin distribution by HPLC in various tissues revealed higher blood concentration of this drug, when given in free form, compared to its liposomised form. These studies suggest that liposomal Hamycin is more effective than free Hamycin in controlling the experimental Aspergillosis.en_US
dc.description.affiliationDepartment of Biochemistry, University of Delhi, India.en_US
dc.identifier.citationMoonis M, Ahmad I, Bachhawat BK. Liposomal hamycin in the control of experimental aspergillosis in mice: relative toxicity, therapeutic efficacy and tissue distribution of free and liposomal hamycin. Indian Journal of Biochemistry & Biophysics. 1992 Aug; 29(4): 339-45en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28372
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibiotics, Antifungal --administration & dosageen_US
dc.subject.meshAspergillosis --drug therapyen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshLethal Dose 50en_US
dc.subject.meshLiposomesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshPolyenes --administration & dosageen_US
dc.subject.meshTissue Distributionen_US
dc.titleLiposomal hamycin in the control of experimental aspergillosis in mice: relative toxicity, therapeutic efficacy and tissue distribution of free and liposomal hamycin.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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