Anti-cholinergic alkaloids as potential therapeutic agents for Alzheimer’s disease: An in silico approach.

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dc.contributor.authorNaaz, Huma
dc.contributor.authorSingh, Swati
dc.contributor.authorPandey, Veda P
dc.contributor.authorSingh, Priyanka
dc.contributor.authorDwivedi, Upendra N
dc.date.accessioned2013-07-17T05:34:13Z
dc.date.available2013-07-17T05:34:13Z
dc.date.issued2013-04
dc.description.abstractAlzheimer’s disease (AD), a progressive neurodegenerative disorder with many cognitive and neuropsychiatric symptoms is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine (ACh). Plant-derived metabolites, including alkaloids have been reported to possess neuroprotective properties and are considered to be safe, thus have potential for developing effective therapeutic molecules for neurological disorders, such as AD. Therefore, in the present study, thirteen plant-derived alkaloids, namely pleiocarpine, kopsinine, pleiocarpamine (from Pleiocarpa mutica, family: Annonaceae), oliveroline, noroliveroline, liridonine, isooncodine, polyfothine, darienine (from Polyalthia longifolia, family: Apocynaceae) and eburnamine, eburnamonine, eburnamenine and geissoschizol (from Hunteria zeylanica, family: Apocynaceae) were analyzed for their anti-cholinergic action through docking with acetylcholinesterase (AChE) as target. Among the alkaloids, pleiocarpine showed promising anti-cholinergic potential, while its amino derivative showed about six-fold higher anti-cholinergic potential than pleiocarpine. Pleiocarpine and its amino derivative were found to be better inhibitors of AChE, as compared to commonly used drugs tacrine (brand name: Cognex) and rivastigmine (brand name: Exelon), suggesting development of these molecules as potential therapeutics in future.en_US
dc.identifier.citationNaaz Huma, Singh Swati, Pandey Veda P, Singh Priyanka, Dwivedi Upendra N. Anti-cholinergic alkaloids as potential therapeutic agents for Alzheimer’s disease: An in silico approach. Indian Journal of Biochemistry & Biophysics. 2013 Apr; 50(2): 120-125.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147295
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/17097en_US
dc.subjectAnti-cholinergicen_US
dc.subjectAnti-cholinesteraseen_US
dc.subjectAlkaloidsen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectPleiocarpineen_US
dc.subjectMolecular dockingen_US
dc.subjectPleiocarpineen_US
dc.subject.meshAlkaloids --chemistry
dc.subject.meshAlkaloids --pharmacology
dc.subject.meshAlzheimer Disease --metabolism
dc.subject.meshCatalytic Domain
dc.subject.meshChemistry, Pharmaceutical --methods
dc.subject.meshCholinergic Antagonists --pharmacology
dc.subject.meshCholinesterase Inhibitors --pharmacology
dc.subject.meshCrystallography, X-Ray --methods
dc.subject.meshDrug Design
dc.subject.meshHumans
dc.subject.meshHydrogen Bonding
dc.subject.meshLigands
dc.subject.meshModels, Chemical
dc.subject.meshModels, Molecular
dc.subject.meshPhytotherapy
dc.subject.meshProtein Binding
dc.subject.meshProtein Conformation
dc.subject.meshQuantitative Structure-Activity Relationship
dc.subject.otherAlzheimer Disease --drug therapy
dc.subject.otherDatabases, Protein
dc.titleAnti-cholinergic alkaloids as potential therapeutic agents for Alzheimer’s disease: An in silico approach.en_US
dc.typeArticleen_US
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