Supplementation of Madhuca longifolia Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach-Supplemenntary data

Simple item page
dc.contributor.authorSimon Peter, Jerineen_US
dc.contributor.authorNithiyanandam, Sangeethaen_US
dc.contributor.authorKatturajan, Ramkumaren_US
dc.contributor.authorParthasarathy, Manishaen_US
dc.contributor.authorNamachivayam, Arunrajen_US
dc.contributor.authorHiraganahalli Bhaskarmurthy, Deepaken_US
dc.contributor.authorR, Vidyaen_US
dc.contributor.authorEvan Prince, Sabinaen_US
dc.date.accessioned2023-08-09T06:03:09Z
dc.date.available2023-08-09T06:03:09Z
dc.date.issued2023-03
dc.description.abstractDiclofenac medication has been extensively used for anti-inflammatory, anti-pyretic, and analgesic actions. Its abiding usage and overdose have induced toxicity and harmful effects on the liver, kidney, and gastrointestinal tract. The research aims to scrutinize the protective effect of Madhuca longifolia seed oil against diclofenac-induced toxicity in female Wistar albino rats. A period of 10 days of study was aimed at 7 groups; Group 1 was assigned as normal control. Group 2 has been administered diclofenac (50 mg/kg b.w. /day, i.p.) only on the last two days of each study period. Group 3 and Group 4 have been pre-treated with 1 mL, and 2 mL of Madhuca longifolia seed oil, respectively, and diclofenac was induced as per Group 2. Group 5 was treated with the standard drug silymarin and diclofenac. Group 6 and Group 7 were given 1 mL and 2 mL of Madhuca longifolia seed oil alone. After the study period, parameters like liver enzyme markers, renal enzyme markers, and antioxidants were measured, and tissue samples were analyzed for histopathological changes. The results proved that pre-treatment of 1 mL of Madhuca longifolia seed oil has efficacy against diclofenac-induced toxicity.en_US
dc.identifier.affiliationsSchool of Biosciences and Technologyen_US
dc.identifier.affiliationsVIT School of Agricultural innovations and Advance Learning (VAIAL), VIT, Vellore-632 014, Tamil Nadu, Indiaen_US
dc.identifier.citationSimon Peter Jerine, Nithiyanandam Sangeetha, Katturajan Ramkumar, Parthasarathy Manisha, Namachivayam Arunraj, Hiraganahalli Bhaskarmurthy Deepak, R Vidya, Evan Prince Sabina. Supplementation of Madhuca longifolia Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach-Supplemenntary data. Indian Journal of Biochemistry & Biophysics. 2023 Mar; 60(3): 186-195en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221630
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber3en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.56042/ijbb.v60i3.69793en_US
dc.subjectAntioxidanten_US
dc.subjectDiclofenacen_US
dc.subjectGastrointestinal toxicityen_US
dc.subjectHepatotoxicityen_US
dc.subjectMadhuca longifolia seed oilen_US
dc.subjectRenal toxicityen_US
dc.titleSupplementation of Madhuca longifolia Seed oil augments diclofenac-induced organ toxicities: A biochemical and histopathological approach-Supplemenntary dataen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJBB2023v60n3p186b.pdf
Size:
238.2 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Biochemistry & Biophysics