Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides.
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2001-08-23
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Abstract
Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. The inhibition of MAO-A by MCP is reversible whereas the inhibition by DDVP and phosphamidon is irreversible. MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO.
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Nag M, Nandy N. Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides. Indian Journal of Experimental Biology. 2001 Aug; 39(8): 802-6