Liquid membrane phenomenon in the actions of digitalis.
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1991-02-01
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Abstract
The liquid membrane phenomenon in the actions of digitalis glycosides (digitoxin, digoxin and ouabain) has been studied. Formation of liquid membranes, in series with a supporting membrane, by digitalis alone and by digitalis in association with lecithin and cholesterol has been demonstrated. The results obtained on the transport of relevant permeants, viz. sodium, potassium and calcium ions and dopamine, adrenaline, noradrenaline and serotonin, in the presence of the liquid membrane generated by digitalis in association with lecithin and cholesterol indicate that the liquid membrane barrier to transport may have a relevance with the biological actions of digitalis.
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Singh V, Malhotra B, Raju DB, Nagappa AN, Srivastava RC. Liquid membrane phenomenon in the actions of digitalis. Indian Journal of Biochemistry & Biophysics. 1991 Feb; 28(1): 34-9