Cellular AATF gene: armour against HIV-1.
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2007-10-18
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Abstract
Outcome of HIV-1 infection at the cellular level is decided by the orchestrated balance that exists between cellular nucleic acid-based adaptive immune mechanism involving non-coding micro RNAs (miRNAs) and offensive tactics of HIV-1 to suppress this host cellular immunity. In this context, the review explains the importance of a novel miRNA encoded exclusively and conspicuously by HIV-1 genome that has the ability to specifically target cellular AATF gene recognized to play a crucial role in the maintenance of adaptive immunity at nucleic acid level against HIV-1 invasion.
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15 references.
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Kaul D. Cellular AATF gene: armour against HIV-1. Indian Journal of Biochemistry & Biophysics. 2007 Oct; 44(5): 276-8