Conjugation of proteins and enzymes with hydrophilic polymers and their applications.
No Thumbnail Available
Date
1991-10-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The efficacy of a number of therapeutically active proteins and peptides is severely limited due to their instability in circulation. Of the various approaches used to stabilise these proteins, the one more successful is covalent modification of the protein or enzyme with some hydrophilic polymers such as dextran or PEG. These conjugates are more stable than the native protein both in vitro as well as in vivo. They exhibit enhanced resistant to proteolytic degradation, have a long-life in circulation and exhibit reduced immunogenicity. The therapeutic efficacy of these conjugates is also greatly enhanced compared to the native protein or enzyme.
Description
56 references.
Keywords
Citation
Mumtaz S, Bachhawat BK. Conjugation of proteins and enzymes with hydrophilic polymers and their applications. Indian Journal of Biochemistry & Biophysics. 1991 Oct-Dec; 28(5-6): 346-51