Effect of aspirin on isoproterenol induced changes in lipid metabolism in rats.
No Thumbnail Available
Date
1993-02-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The effect of aspirin on isoproterenol induced changes in lipid metabolism in rats was studied. Aspirin (1.2 mg/100 g/day) was administered orally for a period of 60 days along with/without isoproterenol (20 mg/100g sc twice at a time interval of 24 h for 2 days). Isoproterenol treated rats showed an increase in the levels of heart cholesterol, triglycerides and free fatty acids. The activity of cholesterol ester synthetase CES was increased significantly with concomitant increase in heart lipid peroxide levels in isoproterenol treatment. Aspirin treatment could restore the enzyme activity to near normal and also reduce the level of lipid peroxides. The lipid changes were minimum in rats treated with aspirin and isoproterenol.
Description
Keywords
Citation
Manjula TS, Devi CS. Effect of aspirin on isoproterenol induced changes in lipid metabolism in rats. Indian Journal of Medical Research. 1993 Feb; 98(): 30-3