Anti-depressant activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats.
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Date
2020-01
Journal Title
Journal ISSN
Volume Title
Publisher
Krishna Institute of Medical Sciences University
Abstract
Background: Depression is one of the most commontypes of neurological disorder, which is a markedpattern of disturbances in emotional behavior, memoryand hedonic processing. Aim and Objectives: Toinvestigate the role of ethanolic extract of Theobromacacao seed on the prefrontal cortex of female Wistarrats following reserpine-induced depression. Materialand Methods: Thirty-six (36) female Wistar rats wereused for this study. They were divided into six (A - F)groups (n = 6). Group A- control, Group B - 0.2 mg/kgreserpine, Group C - 10 mg/kg fluoxetine, Group D -500 mg/kg Theobroma cacao seed extract, Group E -0.2 mg/kg reserpine + 500mg/kg Theobroma cacaoseed extract, Group F - 0.2 mg/kg reserpine + 10mg/kgfluoxetine. Animals were euthanized via cervicaldislocation after the last day of administration and theprefrontal cortex and hippocampus were excised andfixed in 10% formalin solution for routine histologicalprocessing while the part used for biochemical assaywere homogenized in phosphate buffer beforecentrifugation. Results: Morphological alteration andreduced population of prefrontal cortex andhippocampus neurons, reduced protein synthesis, poorbehavioral patterns, reduced neurotransmission andinduction of oxidative stress in reserpine exposedanimal. Conclusion: Theobroma cacao seed extractwas able to mitigate these aberrations.
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Keywords
Depression, Reserpine, Prefrontal Cortex, Hippocampus, Theobroma cacao
Citation
Adebola Adetunji Opeyemi, Ayodeji Ayannuga Olugbenga, Adetayo Lawal Ismail, Adeboye Ezekwem Chukwuebuka, Toyin Adetunji Iyabode. Anti-depressant activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats.. Journal of Krishna Institute of Medical Sciences University. 2020 Jan; 9(1): 27-35