Citrullus lanatus Ethanolic Seed Extract Improved Male Sexual Behavior in Rats via Enhancement of Sexual Hormone and Hypothalamic-Pituitary-Gonadal Pathway.
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Date
2019-07
Journal Title
Journal ISSN
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Publisher
Krishna Institute of Medical Sciences University
Abstract
Background: Current drugs used for sexual dysfunction have several limitations, necessitating the search for alternative medicine. Aim and Objective: The study investigated the effect of Citrullus lanatus ethanolic seed extract (CLESE) on the sexual behavior and reproductive hormones of adult male Wistar rats. Material and Methods: Twenty-four adult male Wistar rats were randomized into four groups (n=6). Group 1 received saline (1 ml/kg, p.o.) and served as normal control, groups 2 and 3 were given CLESE (500 and 1000 mg/kg, p.o.) for 14 consecutive days. Group 4 received Sildenafil Citrate (SC) (5 mg/kg, p.o.), which served as positive control drug and this was administered 4 h before sexual behavioral test only on days 7 and 14. Sexual behavioral tests were performed in a Plexiglas copulatory arena. Male sexual behavioral parameters were evaluated following one on one exposure of experimental male rats with oestrusinduced sexual seeking female rats. Thereafter, rats were sacrificed. Results: CLESE enhanced ibido by significantly (p < 0.05) increasing mounting and intromission frequencies relative to normal controls. CLESE also enhanced intromission and ejaculation latencies, but decreased mounting latency and post ejaculatory interval. Serum testosterone and luteinizing hormone were also significantly (p < 0.05) increased. The histological findings showed improved histoarchitechture of the testes and hypothalamic sections. Conclusion: The findings from this study showed that CLESE enhanced sexual behavior via mechanism related to increased serum testosterone and luteinizing hormone and may be useful for men with sexual dysfunction.
Description
Keywords
Citrullus lanatus, Male Sexual Dysfunction, Sexual Behavior, Impotence
Citation
Onyinye Atuadu Vivian, Emeka Anyanwu Godson. Citrullus lanatus Ethanolic Seed Extract Improved Male Sexual Behavior in Rats via Enhancement of Sexual Hormone and Hypothalamic-Pituitary-Gonadal Pathway.. Journal of Krishna Institute of Medical Sciences University. 2019 Jul; 8(3): 96-107