The association between survivin −31G>C polymorphism and susceptibility to sporadic colorectal cancer in a Southern Chinese population
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Date
2019-01
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer India Pvt. Ltd.
Abstract
Background: The case–control study aimed to investigate the association between the −31G>C polymorphism in the promoter of survivin gene and the susceptibility to sporadic colorectal cancer (CRC) in a Southern Chinese population. Materials and Methods: The study was carried out on 711 healthy controls and 702 CRC cases of a Southern Chinese population. Survivin gene −31G>C genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The association between CRC risk and −31G>C genetic polymorphism was estimated using an unconditional logistic regression model. Results: The number of CC genotype carried in CRC patients was much higher than those of controls (P < 0.001). Compared with CC genotypes, GC, GG genotypes and −31G wild-type genotypes (i.e., GC + GG) had a significantly decreased risk of CRC (P < 0.001). In addition, survivin −31G wild-type genotypes were not associated with decreased risk of sporadic CRC patients with body mass index (BMI) ≥28.0 kg/m2, family cancer history, and premenopausal. Conclusion: Survivin −31G>C polymorphism is associated with sporadic CRC risk in the Southern Chinese population. The −31G wild-type genotypes and GC, GG genotypes are the independent protective factors against sporadic CRC excluding those with a BMI ≥28.0 kg/m2, family cancer history, and premenopausal
Description
Keywords
Clinical research, colorectal cancer, genetic susceptibility, single nucleotide polymorphism, survivin
Citation
Huang Jun, Wei Yisheng, Zhou Xiaodong, Wang Lei, Huang Meijin, Wang Jianping. The association between survivin −31G>C polymorphism and susceptibility to sporadic colorectal cancer in a Southern Chinese population. Journal of Cancer Research and Therapeutics. 2019 Jan; 15(1): 82-86