The association between survivin −31G>C polymorphism and susceptibility to sporadic colorectal cancer in a Southern Chinese population

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dc.contributor.authorHuang, Junen_US
dc.contributor.authorWei, Yishengen_US
dc.contributor.authorZhou, Xiaodongen_US
dc.contributor.authorWang, Leien_US
dc.contributor.authorHuang, Meijinen_US
dc.contributor.authorWang, Jianpingen_US
dc.date.accessioned2020-11-18T10:07:22Z
dc.date.available2020-11-18T10:07:22Z
dc.date.issued2019-01
dc.description.abstractBackground: The case–control study aimed to investigate the association between the −31G>C polymorphism in the promoter of survivin gene and the susceptibility to sporadic colorectal cancer (CRC) in a Southern Chinese population. Materials and Methods: The study was carried out on 711 healthy controls and 702 CRC cases of a Southern Chinese population. Survivin gene −31G>C genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The association between CRC risk and −31G>C genetic polymorphism was estimated using an unconditional logistic regression model. Results: The number of CC genotype carried in CRC patients was much higher than those of controls (P < 0.001). Compared with CC genotypes, GC, GG genotypes and −31G wild-type genotypes (i.e., GC + GG) had a significantly decreased risk of CRC (P < 0.001). In addition, survivin −31G wild-type genotypes were not associated with decreased risk of sporadic CRC patients with body mass index (BMI) ≥28.0 kg/m2, family cancer history, and premenopausal. Conclusion: Survivin −31G>C polymorphism is associated with sporadic CRC risk in the Southern Chinese population. The −31G wild-type genotypes and GC, GG genotypes are the independent protective factors against sporadic CRC excluding those with a BMI ≥28.0 kg/m2, family cancer history, and premenopausalen_US
dc.identifier.affiliationsDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006; Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Chinaen_US
dc.identifier.affiliationsDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, Chinaen_US
dc.identifier.affiliationsDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Chinaen_US
dc.identifier.affiliationsDepartment of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Chinaen_US
dc.identifier.affiliationsDepartment of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Chinaen_US
dc.identifier.affiliationsDepartment of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Chinaen_US
dc.identifier.citationHuang Jun, Wei Yisheng, Zhou Xiaodong, Wang Lei, Huang Meijin, Wang Jianping. The association between survivin −31G>C polymorphism and susceptibility to sporadic colorectal cancer in a Southern Chinese population. Journal of Cancer Research and Therapeutics. 2019 Jan; 15(1): 82-86en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213433
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/0973-1482.202894en_US
dc.subjectClinical researchen_US
dc.subjectcolorectal canceren_US
dc.subjectgenetic susceptibilityen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectsurvivinen_US
dc.titleThe association between survivin −31G>C polymorphism and susceptibility to sporadic colorectal cancer in a Southern Chinese populationen_US
dc.typeJournal Articleen_US
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