Evaluation Of Antihyperlipidemic Activity Of Ethanolic Extract Of Crossandra Infundibuliformis Leaves And Stems On High Fat Diet Induced Hyperlipidemia
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Date
2020-03
Journal Title
Journal ISSN
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Publisher
MRI Publication Pvt. Ltd.
Abstract
Hypercholesterolaemia is the state been depicted by an expanded greasy substances called lipids, rise in plasma TCs and TGs levels it is additionally called hyper lipoproteinemia. The present study was designed to investigate the hypolipidemic effect of ethanolic extract of Crossandra infundibuliformis leaves and stem (ECILS) in high fat diet (cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal laboratory feed) . The rats feed with High-fat diet containing (cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal standard laboratory feed) for 1 month, and then they are checked for the blood parameter levels like TC, TGs, LDL, VLDL, and HDL. Ethanolic extracts at low dose (100 mg/kg), significantly reduced the levels of TC, TGL, LDL, VLDL & increased the levels of HDL and reduced the body weights on 30st day, and at medium, high doses it reduced the levels of TC, TGL, LDL, VLDL & increased the levels of HDL and reduced the body weights.
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Keywords
Crossandra infundibuliformis, Hyperlipoidemia, Sprague Dawley rats, ECILS
Citation
Vasantha G., Venkatesham A., Dayakar C. H.. Evaluation Of Antihyperlipidemic Activity Of Ethanolic Extract Of Crossandra Infundibuliformis Leaves And Stems On High Fat Diet Induced Hyperlipidemia. International Journal of Pharmaceutical Sciences and Drug Research. 2020 Mar; 12(2): 136-140