Anticancer and Molecular Docking Studies of 1-(5-substituted phenyl) isoxazol-3-yl)-5-phenyl-1H-tetrazoles
Loading...
Date
2019-07
Journal Title
Journal ISSN
Volume Title
Publisher
Science Domain International
Abstract
Cancer a leading cause of human mortality worldwide is characterised by the unseemly growth of cellular mass and signalled through the enlargement of stress. Management of cancer treatment is still buried andhas been recently alerting the need to discover a drug molecule with lesser side effects. The objective of the present study is to explore the anticancer activity and docking studies of 1-(5-substituted phenyl) isoxazol-3-yl)-5-phenyl-1H-tetrazole derivatives. The compounds were evaluated for in-vitroanticancer activity under the drug discovery program of National Cancer Institute (NCI), USA. Only seven compounds were selected and screened for anticancer activity at a single high dose (10-5M) using NCI 60 cancer cell lines. Among all the selected compounds, 4band 4iexhibited significant anticancer activity against Leukemia cell lines. Molecular docking studies for the 5-phenyl-1-(5-substituted phenylisoxazol-3-yl)-1H-tetrazole analogues was done by Schrodinger software. Docking results stated that the compounds 4band 4ihas good dock score among the other derivatives which shows good binding efficiency towards receptor
Description
Keywords
Sodium azide, isoxazole, tetrazole, renal cancer, breast cancer, molecular docking
Citation
Kaushik N., Kumar N., Kumar A., Kumar S., Chaudhary B. K.. Anticancer and Molecular Docking Studies of 1-(5-substituted phenyl) isoxazol-3-yl)-5-phenyl-1H-tetrazoles . International Journal of Biochemistry Research & Review. 2019 Jul; 26(3): 1-12