The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis

Objectives The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A. Methods Information related to the sample size and genotype frequencies was extracted from each study. Results Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy. Conclusions Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy.

Keywords

Left ventricular hypertrophy, Angiotensin-converting enzyme, ACE I/D, ACE G2350A

Citation

Fajar Jonny Karunia, Pikir Budi Susetio, Sidarta Erdo Puncak, Saka Putu Nina Berlinda, Akbar Rizal Rahmanda, Heriansyah Teuku. The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis. Indian Heart Journal. 2019 May; 71(3): 199-206

URI

https://imsear.searo.who.int/handle/123456789/191690

Collections

Indian Heart Journal

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