The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis

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dc.contributor.authorFajar, Jonny Karuniaen_US
dc.contributor.authorPikir, Budi Susetioen_US
dc.contributor.authorSidarta, Erdo Puncaken_US
dc.contributor.authorSaka, Putu Nina Berlindaen_US
dc.contributor.authorAkbar, Rizal Rahmandaen_US
dc.contributor.authorHeriansyah, Teukuen_US
dc.date.accessioned2020-01-02T06:40:27Z
dc.date.available2020-01-02T06:40:27Z
dc.date.issued2019-05
dc.description.abstractObjectives The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A. Methods Information related to the sample size and genotype frequencies was extracted from each study. Results Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy. Conclusions Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy.en_US
dc.identifier.affiliationsMedical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesiaen_US
dc.identifier.affiliationsDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60115, Indonesiaen_US
dc.identifier.affiliationsBrawijaya Cardiovascular Research Center, Universitas Brawijaya, Malang, 65145, Indonesiaen_US
dc.identifier.affiliationsDepartment of Emergency, Wava Husada Hospital, Malang, 65163, Indonesiaen_US
dc.identifier.affiliationsDepartment of Cardiology and Vascular Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesiaen_US
dc.identifier.citationFajar Jonny Karunia, Pikir Budi Susetio, Sidarta Erdo Puncak, Saka Putu Nina Berlinda, Akbar Rizal Rahmanda, Heriansyah Teuku. The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis. Indian Heart Journal. 2019 May; 71(3): 199-206en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/191690
dc.languageenen_US
dc.publisherCardiological Society of Indiaen_US
dc.relation.issuenumber3en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2019.07.002en_US
dc.subjectLeft ventricular hypertrophyen_US
dc.subjectAngiotensin-converting enzymeen_US
dc.subjectACE I/Den_US
dc.subjectACE G2350Aen_US
dc.titleThe Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysisen_US
dc.typeJournal Articleen_US
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