Novel Cathelicidin Antimicrobial Peptides from Paa robertingeri
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Date
2019-07
Journal Title
Journal ISSN
Volume Title
Publisher
Science Domain International
Abstract
This study aimed to describe two cathelicidins (cathelicidin-PR1 and cathelicidin-PR2) from the skin of Paa robertingeri (Anura: Ranidae). The deduced mature peptides cathelicidin-PR1 and cathelicidin-PR2 were composed of 29 and 25 residues, respectively. Cathelicidin - PR1 has higher antimicrobial activity it could kill Gram-positive and Gram-negative bacteria and even some fungal species. Cathelicidin-PR1 exhibited more effective than AMP in antimicrobial activity against Pseydomonas maltophilia clinical strain. On the contrary, cathelicidin-PR2 had very weak antimicrobial activity. Furthermore, cathelicidin-PR1 and cathelicidin-PR2 exhibited very low hemolytic activity against human erythrocytes and little hemagglutinating activity. The results suggested that the cathelicidin-PR1 might serve as a template for developing novel antibiotics.
Description
Keywords
Antimicrobial activity, antimicrobial peptide, hemagglutinating activity, hemolytic activity, Paa robertingeri
Citation
Luo Qinghua, Deng Huaiqing, Yin Mengguang, Chen Chen, Zhou Jiang. Novel Cathelicidin Antimicrobial Peptides from Paa robertingeri. Annual Research & Review in Biology. 2019 Jul; 32(4): 1-10