Novel Cathelicidin Antimicrobial Peptides from Paa robertingeri

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dc.contributor.authorLuo, Qinghuaen_US
dc.contributor.authorDeng, Huaiqingen_US
dc.contributor.authorYin, Mengguangen_US
dc.contributor.authorChen Chenen_US
dc.contributor.authorZhou, Jiangen_US
dc.date.accessioned2019-12-06T09:19:07Z
dc.date.available2019-12-06T09:19:07Z
dc.date.issued2019-07
dc.description.abstractThis study aimed to describe two cathelicidins (cathelicidin-PR1 and cathelicidin-PR2) from the skin of Paa robertingeri (Anura: Ranidae). The deduced mature peptides cathelicidin-PR1 and cathelicidin-PR2 were composed of 29 and 25 residues, respectively. Cathelicidin - PR1 has higher antimicrobial activity it could kill Gram-positive and Gram-negative bacteria and even some fungal species. Cathelicidin-PR1 exhibited more effective than AMP in antimicrobial activity against Pseydomonas maltophilia clinical strain. On the contrary, cathelicidin-PR2 had very weak antimicrobial activity. Furthermore, cathelicidin-PR1 and cathelicidin-PR2 exhibited very low hemolytic activity against human erythrocytes and little hemagglutinating activity. The results suggested that the cathelicidin-PR1 might serve as a template for developing novel antibiotics.en_US
dc.identifier.affiliationsSchool of Life Sciences, Guizhou Normal University, Guiyang, Guizhou, 550001, China.en_US
dc.identifier.affiliationsSchool of Life Sciences, Guizhou Normal University, Guiyang, Guizhou, 550001, China.en_US
dc.identifier.affiliationsSchool of Life Sciences, Guizhou Normal University, Guiyang, Guizhou, 550001, China.en_US
dc.identifier.affiliationsSchool of Life Sciences, Guizhou Normal University, Guiyang, Guizhou, 550001, China.en_US
dc.identifier.affiliationsSchool of Life Sciences, Guizhou Normal University, Guiyang, Guizhou, 550001, China.en_US
dc.identifier.citationLuo Qinghua, Deng Huaiqing, Yin Mengguang, Chen Chen, Zhou Jiang. Novel Cathelicidin Antimicrobial Peptides from Paa robertingeri. Annual Research & Review in Biology. 2019 Jul; 32(4): 1-10en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188047
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/arrb/2019/v32i430093en_US
dc.subjectAntimicrobial activityen_US
dc.subjectantimicrobial peptideen_US
dc.subjecthemagglutinating activityen_US
dc.subjecthemolytic activityen_US
dc.subjectPaa robertingerien_US
dc.titleNovel Cathelicidin Antimicrobial Peptides from Paa robertingerien_US
dc.typeJournal Articleen_US
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