Glycaemic Evaluation of Murraya koenigii in Alloxan-induced Diabetic Rabbits.
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Date
2015
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Abstract
Background: Study was aimed to evaluate the antidiabetic activity of Murraya koenigii, a
traditional medicinal plant (Curry leaf) in normoglycemic and alloxan-induced diabetes rabbits.
Methods: Antidiabetic activity of aqueous extract of M. koenigii in 100, 200 300 mg/k doses was
determined by estimating blood glucose before and at 1, 2, 4, 8, 24, and 72 hours post treatment
intervals in treated rabbits. Results: Aqueous extract of Murraya koenigii showed a dose dependent antidiabetic activity with
maximum effect established at 300 mg/kg. The extract also exhibited a significant (p<0.05) dosedependent
hypoglycemic effect on normal and alloxan-induced diabetic rabbits.
Conclusion: Murraya koenigii causes a reduction in blood glucose. This hypoglycemic property
supports-its usein folkloric medicine as an antidiabetic agent and thus suggests a place for it in
nutritional therapy in the management of diabetes mellitus and thus as an oral hypoglycaemic
agent.
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Keywords
Murraya koenigii, hypoglycemic effect, alloxan-induced diabetes
Citation
Akande T, Balogun S T, Abdullahi H, Ogundeko O T, Ramyil M S. Glycaemic Evaluation of Murraya koenigii in Alloxan-induced Diabetic Rabbits. International Journal of Biochemistry Research & Review 2015 7(4): 175-181.