Evaluation of Aqueous Leaf Extract of Cissampelos mucronata on Testicular Function Indices in Wistar Rats.
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Date
2015
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Abstract
Aim: This study aimed at investigating the effect of aqueous leaf extract of Cissampelos mucronata
on testicular function indices in male wistar rats (Rattus novergicus).
Methodology: A total of 20 rats, grouped into four, with a group consisting of five rats were used
for the study. The groups were a control administered 1.0 mL of distilled water and three other
groups that were respectively administered - 1.0 mL of 300, 600 and 1200 mg/kg body weight of
the plant extract. The different groups were administered plant extract orally for 14 days, using
metal oropharyngeal cannula. Results: The results revealed a significant increase (P <0.05) in body weight, testes-body weight
ratio, cholesterol and glycogen concentrations at all the doses except at 1200 mg/kg body weight of
the animals where decreased glycogen level was observed. There was also significant decrease (P
<0.05) in the concentrations of acid phosphatase, alkaline phosphatase and total testicular protein
especially in rats administered with 1200 mg/kg body weight of extract while there was no
significant change in the activities of gamma glutamyl transferase. Serum testosterone
concentration was observed to decrease significantly (P <0.05) only in the rats administered with
300 mg/kg body weight of extract.
Conclusion: The results indicate anti-androgenic and anti-steroidogenic activities of Cissampelos
mucronata aqueous leaf extract on males.
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Keywords
Cissampelos mucronata, testicular function indices, anti-androgenic, anti-steroidogenic
Citation
Olaolu T D, Akinwande O G, Olaolu A P. Evaluation of Aqueous Leaf Extract of Cissampelos mucronata on Testicular Function Indices in Wistar Rats. International Journal of Biochemistry Research & Review 2015 5(4): 233-241.