Association between Follicle Stimulating Hormone Receptor (FSHR) Polymorphism and Polycystic Ovary Syndrome among Egyptian Women.
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Date
2015
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Abstract
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder and the criteria are
specified by common complex genetic hyperandrogenism, oligomenorrhea or amenorrhea and
polycystic ovary morphology. It is a leading cause of female infertility. The prevelance of PCOS
among reproductive age women has been estimated to be 4-12%. The association between PCOS
and FSH receptor (FSHR) polymorphism attracts wide attention. The aim of the present study was
to evaluate whether polymorphism of FSHR at Ala307Thr codon is associated with PCOS and with clinical features of PCOS patients in Egypt.
Results: PCOS patients (n=64) and control subjects (n=65) in the reproductive age were recruited
from the outpatient clinic of Obstetrics and Gynecology Department, Mansoura University, Egypt.
The Ala307Thr polymorphism in FSHR, and the frequency of respective genotypes was studied
and statistical analysis was performed. We found that the heterozygote Ala/Thr genotype was
associated with PCOS (64.1%, OR=2.68, CI=0.97, P= 0.033) compared with controls.
Conclusion: The variant of Ala307Thr polymorphism of FSHR was associated with PCOS but it
may be related to high total testosterone levels. In addition the FSHR polymorphism was not
associated with either luteinizing hormone or follicular stimulating hormone. The present study
suggests that the variant of the FSHR gene may act as a causative factor of PCOS in Egyptian
women.
Description
Keywords
Polycystic ovary syndrome, follicle stimulating hormone, follicle stimulating hormone receptor, single nucleotide polymorphisms
Citation
Abdel-Aziz A F, El-Sokkary A M A, El-Refaeey A A, El-Sokkary M M A, Osman H G, El-Saeed Rasha A. Association between Follicle Stimulating Hormone Receptor (FSHR) Polymorphism and Polycystic Ovary Syndrome among Egyptian Women. International Journal of Biochemistry Research & Review 2015 5(3): 198-206.