Impaired Renal Function is Associated with Severe Coronary Artery Disease in Chronic Stable Angina Patients.
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Date
2014
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Abstract
Background: Cardiovascular disease is the leading cause of morbidity and mortality in renal impaired
patients. Many of the patients of chronic kidney disease die of cardiovascular disease before requiring
dialysis. Cardiovascular disease in renal impaired patient is potentially preventable and treatable. The
aim of this study was to evaluate the association between renal impairment and coronary artery disease
severity in chronic stable angina patients.
Methods: 110 patients with chronic stable angina who got admitted for coronary angiography were included
in the study. They were divided into impaired renal function group (with estimated glomerular filtration
rate [eGFR] <90 ml/min/1.73m2) and normal renal function group (eGFR e” 90 ml/min/1.73m2) on the
basis of eGFR. The severity of the CAD was assessed by angiographic Vessel score and Gensini score.
Results: Mean Gensini score was significantly high in impaired renal function group (42.30±24.9 vs
25.65±17.9, p <0.05). There was significant negative correlation between eGFR and vessel score (r=-0.30, p
<0.05) and between eGFR and Gensini score (r =-0.65, P <0.05). In multivariate logistic regression analysis,
after adjustment of factors eGFR remain independent predictors of severe CAD (P=0.002, OR -5.73).
Conclusion: Impaired renal function, assessed by eGFR is associated with angiographic severe coronary
artery disease in chronic stable angina patients and this association is independent of conventional
cardiovascular risk factors.
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Keywords
Renal Impairment, Coronary Artery Disease
Citation
Saha J N, Majumder A A S, Chowdhury N A, Ullah M, Azam M G, Karmoker K K, Islam M J, Das P R, Islam M S Mamunuzzaman M, Biswas P, Rahman M A. Impaired Renal Function is Associated with Severe Coronary Artery Disease in Chronic Stable Angina Patients. Cardiovascular Journal. 2014; 7(1): 17-23.