Evaluation of the Anxiolytic Effect of Methanolic Leaves Extract of Paullinia pinnata Lin in Mice.
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Date
2014-07
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Abstract
This study was designed to evaluate the anxiolytic effect of methanolic leave extract of
Paullinia pinnata L. in mice. The elevated plus-maze and staircase paradigm were used to
assess the anxiolytic activity of the methanolic leaf extract of Paullinia pinnata and
diazepam. The results of the elevated plus-maze test showed that the extract at the dose
of 50 mg/kg and diazepam significantly (P<0.05 and P<0.005) increased both the number
of entries and time spent in the open arm by mice. In staircase paradigm, the extract
produced a significant (P<0.05-P<0.0005) dose dependent decrease in the number of
steps ascended and number of rearing events compared to the control mice. Diazepam
significantly (P<0.0005) reduced the number of rearing events compared to control. The
result of the present preliminary study suggests that methanolic leaf extract of Paullinia
pinnata may possess an anxiolytic activity.
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Keywords
Paullinia pinnata, anxiolytic, elevated plus- maize, staircase, diazepam
Citation
Aliyu M, Anuka J A, Yaro A H, Magaji M G. Evaluation of the Anxiolytic Effect of Methanolic Leaves Extract of Paullinia pinnata Lin in Mice. British Journal of Pharmaceutical Research. 2014 July; 4(13): 1638-1646.