Evaluation of the Anxiolytic Effect of Methanolic Leaves Extract of Paullinia pinnata Lin in Mice.

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dc.contributor.authorAliyu, M
dc.contributor.authorAnuka, J A
dc.contributor.authorYaro, A H
dc.contributor.authorMagaji, M G
dc.date.accessioned2015-09-16T05:18:55Z
dc.date.available2015-09-16T05:18:55Z
dc.date.issued2014-07
dc.description.abstractThis study was designed to evaluate the anxiolytic effect of methanolic leave extract of Paullinia pinnata L. in mice. The elevated plus-maze and staircase paradigm were used to assess the anxiolytic activity of the methanolic leaf extract of Paullinia pinnata and diazepam. The results of the elevated plus-maze test showed that the extract at the dose of 50 mg/kg and diazepam significantly (P<0.05 and P<0.005) increased both the number of entries and time spent in the open arm by mice. In staircase paradigm, the extract produced a significant (P<0.05-P<0.0005) dose dependent decrease in the number of steps ascended and number of rearing events compared to the control mice. Diazepam significantly (P<0.0005) reduced the number of rearing events compared to control. The result of the present preliminary study suggests that methanolic leaf extract of Paullinia pinnata may possess an anxiolytic activity.en_US
dc.identifier.citationAliyu M, Anuka J A, Yaro A H, Magaji M G. Evaluation of the Anxiolytic Effect of Methanolic Leaves Extract of Paullinia pinnata Lin in Mice. British Journal of Pharmaceutical Research. 2014 July; 4(13): 1638-1646.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/163501
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/5097en_US
dc.subjectPaullinia pinnataen_US
dc.subjectanxiolyticen_US
dc.subjectelevated plus- maizeen_US
dc.subjectstaircaseen_US
dc.subjectdiazepamen_US
dc.titleEvaluation of the Anxiolytic Effect of Methanolic Leaves Extract of Paullinia pinnata Lin in Mice.en_US
dc.typeArticleen_US
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