Biocatalytic and electrochemical reduction of selected phenyl alkanones with antibacterial activity of the corresponding phenyl alkanols.
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Date
2011-07
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Abstract
This paper reports the production of some phenyl alkanols by the biocatalytic and
electrochemical reduction of selected Phenyl alkanones viz. Propiophenone, Butyrophenone, and
Valerophenone. Baker‘s yeast was used in its free as well as immobilized form for biocatalytic reduction.
Substrates showed the higher conversion rate when the cells were used in immobilized form. The
electrochemical behavior of substrates was investigated cyclic voltammetrically to explore
electrochemical reduction as alternative synthetic route for the preparation of alcohols. Results obtained
from cyclic voltammetric studies were used for establishing optimum conditions for electrochemical
reduction which was then carried out galvanostatically using economically viable stainless steel (SS-316)
electrodes. The reduction products were isolated and purified by chromatographic techniques and
characterized on the basis of spectral analysis. The products thus obtained also exhibited significant
antibacterial activity against four strains of bacteria viz. Staphylococcus aureus, Enterococcus faecaulis,
Escherichia coli, Pseudomonas aeruginosa.
Description
Keywords
Propiophenone, Butyrophenone, Valerophenone, Baker‘s yeast (BY), Biocatalytic reduction, Immobilized Baker’s yeast (ImBY), Antibacterial Activity, Cyclic Voltammetry, Stainless Steel Electrode (SS-316)
Citation
Sharma Archana, Ojha Poonam, Verma P S, Sharma I K. Biocatalytic and electrochemical reduction of selected phenyl alkanones with antibacterial activity of the corresponding phenyl alkanols. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jul-Sept; 2(3): 277-286.