Effect of diabetes mellitus on the pharmacokinetic behavior of gatifloxacin in sprague-dawley rats.
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Date
2010-11
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Abstract
Effects of diabetes mellitus induced by streptozotocin (DMIS) on the
pharmacokinetics of Gatifloxacin were investigated after i.v and oral administration
(50mg/mg) to control Sprague-Dawley rats and DMIS rats (at 7th and 29th days after
administration of streptozotocin (55mg/kg). After i.v administration to DMIS rats, there
was no significant difference in clearance, t1/2, Vd and MRT last. But after oral
administration of gatifloxacin to DMIS rats Cmax was significantly increased. This could
be supported with the marginal increase in AUC and an increase in bioavailability of drug
in chronic (78.7% increase) as well as acute conditions (75.3% increases). Streptozotocin
induced toxicity did not influence considerably on the pharmacokinetics of gatifloxacin.
Description
Keywords
Diabetes mellitus, Pharmacokinetics, Gatifloxacin
Citation
Wal Pranay, Wal Ankita, Eduru Shravan K, Jain Tarun, Bhandari Anil, Rai Awani K. Effect of diabetes mellitus on the pharmacokinetic behavior of gatifloxacin in sprague-dawley rats. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Nov-Dec; 1(3): 1046-1053.