Effect of diabetes mellitus on the pharmacokinetic behavior of gatifloxacin in sprague-dawley rats.

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dc.contributor.authorWal, Pranay
dc.contributor.authorWal, Ankita
dc.contributor.authorEduru, Shravan K
dc.contributor.authorJain, Tarun
dc.contributor.authorBhandari, Anil
dc.contributor.authorRai, Awani K
dc.date.accessioned2015-07-30T11:17:55Z
dc.date.available2015-07-30T11:17:55Z
dc.date.issued2010-11
dc.description.abstractEffects of diabetes mellitus induced by streptozotocin (DMIS) on the pharmacokinetics of Gatifloxacin were investigated after i.v and oral administration (50mg/mg) to control Sprague-Dawley rats and DMIS rats (at 7th and 29th days after administration of streptozotocin (55mg/kg). After i.v administration to DMIS rats, there was no significant difference in clearance, t1/2, Vd and MRT last. But after oral administration of gatifloxacin to DMIS rats Cmax was significantly increased. This could be supported with the marginal increase in AUC and an increase in bioavailability of drug in chronic (78.7% increase) as well as acute conditions (75.3% increases). Streptozotocin induced toxicity did not influence considerably on the pharmacokinetics of gatifloxacin.en_US
dc.identifier.citationWal Pranay, Wal Ankita, Eduru Shravan K, Jain Tarun, Bhandari Anil, Rai Awani K. Effect of diabetes mellitus on the pharmacokinetic behavior of gatifloxacin in sprague-dawley rats. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Nov-Dec; 1(3): 1046-1053.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/161005
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/Details.aspx?fid=138en_US
dc.subjectDiabetes mellitusen_US
dc.subjectPharmacokineticsen_US
dc.subjectGatifloxacinen_US
dc.titleEffect of diabetes mellitus on the pharmacokinetic behavior of gatifloxacin in sprague-dawley rats.en_US
dc.typeArticleen_US
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