Addition of citral controls ROS and reduces toxicity in 5-fluo rouracil treated Schizosaccharomyces pombe cells.
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Date
2015-03
Authors
Journal Title
Journal ISSN
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Publisher
NISCAIR-CSIR, India
Abstract
In systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination index found was at 0.01 and 0.025 mM of citral with 40 µg or higher concentration of 5-fluorouracil. The combined treatment was so effective that higher number of cells underwent apoptosis compared to individual treatment of 5-fluorouracil. Citral controlled ROS levels and increased survival of normal cells. Several differentially expressed proteins observed in the citral treatment could further help understanding its mechanism of action.
Description
Keywords
Apoptosis, Chemotherapy, Lemongrass, Phytomedicine
Citation
Patel Pinaki B, Thakkar Vasudev R. Addition of citral controls ROS and reduces toxicity in 5-fluorouracil treated Schizosaccharomyces pombe cells. Indian Journal of Experimental Biology. 2015 Mar; 53(3): 152-157.