Addition of citral controls ROS and reduces toxicity in 5-fluo rouracil treated Schizosaccharomyces pombe cells.

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dc.contributor.authorPatel, Pinaki B
dc.contributor.authorThakkar, Vasudev R
dc.date.accessioned2015-06-26T04:16:29Z
dc.date.available2015-06-26T04:16:29Z
dc.date.issued2015-03
dc.description.abstractIn systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination index found was at 0.01 and 0.025 mM of citral with 40 µg or higher concentration of 5-fluorouracil. The combined treatment was so effective that higher number of cells underwent apoptosis compared to individual treatment of 5-fluorouracil. Citral controlled ROS levels and increased survival of normal cells. Several differentially expressed proteins observed in the citral treatment could further help understanding its mechanism of action.en_US
dc.identifier.citationPatel Pinaki B, Thakkar Vasudev R. Addition of citral controls ROS and reduces toxicity in 5-fluorouracil treated Schizosaccharomyces pombe cells. Indian Journal of Experimental Biology. 2015 Mar; 53(3): 152-157.en_US
dc.identifier.issn0975-1009
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158403
dc.language.isoenen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/30740en_US
dc.subjectApoptosisen_US
dc.subjectChemotherapyen_US
dc.subjectLemongrassen_US
dc.subjectPhytomedicineen_US
dc.subject.meshApoptosis --drug effects
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshDrug Evaluation, Preclinical
dc.subject.meshFluorouracil --antagonists & inhibitors
dc.subject.meshFluorouracil --toxicity
dc.subject.meshFungal Proteins --analysis
dc.subject.meshMonoterpenes --pharmacology
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshReactive Oxygen Species --metabolism
dc.subject.meshSchizosaccharomyces --drug effects
dc.subject.meshSchizosaccharomyces --growth & development
dc.subject.meshSchizosaccharomyces --metabolism
dc.titleAddition of citral controls ROS and reduces toxicity in 5-fluo rouracil treated Schizosaccharomyces pombe cells.en_US
dc.typeArticleen_US
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