Angiotensin II inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein.
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Date
2015-04
Journal Title
Journal ISSN
Volume Title
Publisher
NISCAIR-CSIR, India
Abstract
The role of angiotensin II in regulating Na+/K+-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2.-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity.
Description
Keywords
Pulmonary artery smooth muscle cells, Oxidant, Glutathionylation, Na+/K+-ATPase, Na+/K+ATPase inhibitor
Citation
Rahaman Sayed Modinur, Dey Kuntal, Chakraborti Tapati, Chakraborti Sajal. Angiotensin II inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein. Indian Journal of Biochemistry & Biophysics. 2015 Apr; 52 (2): 119-124.