Role of Serum Adiponectin, IL-6 and Hs CRP in Nonalcoholic Fatty Liver Egyptian Patients.
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Date
2014-11
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Abstract
Non alcoholic fatty liver (NAFLD) is accumulation of fat in the
liver cells of peoples who drink little or no alcohol causing mild steatosis with mostly no
signs, symptoms or complication but this may progress to steatohepatitis (NASH) and may
liver cirrhosis then failure. NAFLD is recognized as the most common type of chronic liver
disease in Western countries and the leading cause of cryptogenic cirrhosis. Insulin
resistance (IR) is a key factor in the pathogenesis of NAFLD, the latter being considered
as the hepatic component of IR or metabolic syndrome (MetS). Although the pathogenesis
of NAFLD is not fully elucidated, a complex interaction between adipokines and cytokines
produced by adipocytes and/or inflammatory cells infiltrating adipose tissue appears to
play a crucial role in MetS and NAFLD and its progress. A number of factors are linked
with NAFLD such as obesity, type 2 diabetis mellitus (T2DM), hyperlipidemia, gastric bypass, and its progress to NASH correlate with certain cytokines secreted like
adiponectin, interlukin-6 (IL-6), and C- reactive protein CRP. Adiponectin is a novel
adipocyte-specific protein, which, it has been suggested, plays a role in the development
of insulin resistance and atherosclerosis. The role of (IL-6) in liver pathology is very
complex, and its participation in the development of NAFLD remains unclear. IL-6 is a key
element in the acute phase response, mediating the synthesis of several acute phase
proteins (such as CRP and serum amyloid A). Thus, we cannot exclude the possibility that
IL-6 might also play an indirect deleterious role in NAFLD pathogenesis. In diet-induced
obese mice, treatment with IL-6 antibodies improved sensitivity to insulin.
Objective: This study aim is to evaluate the level of adiponectin, IL-6 and CRP in
Egyptian patients with NAFLD.
Methods: This study was conducted on 2 groups 104 NAFLD as diagnosed by ultrasound
examination and 21 healthy participants as control group. All the subjects were subjected
to an abdominal ultrasonography, liver enzymes ALT & AST, lipid profile (triglycerides,
HDL, LDL, cholesterol, CRP, IL-6 & Adiponectin).
Results: Plasma adiponectin levels were significantly lower in NAFLD patients than
control gp (3.05±2.65μg/ml vs 10.52±3.35 (μg/ml). IL-6 level was higher in NAFLD than
control gp but not significant (114.24±22.32pg/ml vs 104.9±19.98pg/ml). CRP was
significantly higher in NAFLD than control gp (17.86±11.59mg/L vs 5.4±3.81mg/L).
Adiponectin ROC curve showed an AUROC curve in NAFLD gp (0.918 p=0.0001). IL-6
ROC curve showed an AUROC curve in NAFLD gp (0.703 p=0.0003). CRP ROC curve
showed an AUROC curve in NAFLD gp (0.853 p=0.0001).
Conclusion: Patients with NAFLD have lower adiponectin levels and higher IL-6 and CRP
levels compared with their control group.
Description
Keywords
MetS, metabolic syndrome, NAFLD, Non alcoholic fatty liver disease, IL-6, interleukin-6
Citation
Mohamed Amal Ahmed, Shousha Wafaa Gh, Shaker Olfat, El-Sayed Mahdy Mohamed, Ibrahim Eman M A, Mohmoud Sehamm, khairalla Ahmed. Role of Serum Adiponectin, IL-6 and Hs CRP in Nonalcoholic Fatty Liver Egyptian Patients. International Journal of Biochemistry Research & Review 2014 Nov-Dec ; 4 (6) : 493-504.