Antifungal Activity of Terminalia mantaly on the in vitro Growth of Cryptococcus neoformans.
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Date
2013-01
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Abstract
Among the HIV / AIDS infected, individuals contract fungal infections of which many
die as a direct consequence of these infections. In this study, the antifungal activity of
ten extracts (stem bark) from Terminalia mantaly H. Perrier was evaluated on the in
vitro growth of clinical isolate of pathogenic fungi (Cryptococcus neoformans). Agar
double dilution method in slope tubes was adopted to determine anticryptococcal
activity. All extracts exhibited antifungal activity in dose-response relationship. The
residue extracts T4-2 obtained after degreasing the hydro-alcoholic extract T0 (MFC =
24.37μg/Ml; IC50 = 5.87μg/mL) is the most active extract. Moreover, for a given
concentration it is said that there are not significant differences between the different
tests for each extract (P< 0.05). Therefore, using the hydro-alcoholic solvent (70%
ethanol) followed by removal of oil is the best way to obtain an optimally concentrated active ingredient from Terminalia mantaly. The present study justifies the traditional
use of this plant for the treatment of fungal infections.
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Keywords
Antifungal activity, cryptococcosis, opportunists, Terminalia mantaly
Citation
Bognan Ackah Jacques Auguste Alfred, Guillaume Yaye Yapi, Felix Yapi Houphouet, Mathieu Kra Adou Koffi, Joseph Djaman Allico. Antifungal Activity of Terminalia mantaly on the in vitro Growth of Cryptococcus neoformans. International Journal of Biochemistry Research & Review 2013 Jan-Mar ; 3 (1) : 63-73.