Evaluation of Serum Prostate Specific Antigens in Breast Cancer.
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Date
2014-11
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Abstract
Serum Prostate Specific Antigen (PSA) is an established
tumor marker for prostate cancer but its “specificity” for
prostatic diseases was challenged after its extra prostatic
sources and its presence in female serum was detected.
Various studies showed the association of Total PSA (TPSA)
and Free PSA (FPSA) with breast cancer in females. The
present study was conducted to evaluate the status of TPSA
and FPSA as a tumor marker in breast cancer patients. 54
breast cancer cases with 36 fibroadenoma patients along
with 40 controls were selected for the study. Their blood
samples were analyzed for estimation of serum
Testosterone, TPSA and FPSA along with routine
biochemical parameters. 34 breast cancer with 20
fibroadenoma cases were reevaluated for TPSA and FPSA
6 months after tumor removal by surgery. Our observations
revealed high TPSA in the patient group compared to controls
and raised FPSA specifically in breast cancer cases. FPSA
was also found to be the predominant molecular form in
breast cancer cases. A significant positive association was
documented between serum Testosterone and PSA level in
the study group. Both the parameters registered a significant
decline after surgery. On statistical analysis TPSA and FPSA
were found to possess high specificity for breast cancer
cases but were deficient in the desired sensitivity to be
considered as an ideal tumor marker.
Description
Keywords
breast cancer, total PSA, free PSA, tumor marker, sensitivity, specificity
Citation
Dash Prakruti, Mohapatra Prakash Chandra, Mangaraj Manaswini. Evaluation of Serum Prostate Specific Antigens in Breast Cancer. Indian Medical Gazette. 2014 Nov ; 148 (11): 411-418.