Evaluation of Serum Prostate Specific Antigens in Breast Cancer.

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dc.contributor.authorDash, Prakruti
dc.contributor.authorMohapatra, Prakash Chandra
dc.contributor.authorMangaraj, Manaswini
dc.date.accessioned2015-04-21T05:18:02Z
dc.date.available2015-04-21T05:18:02Z
dc.date.issued2014-11
dc.description.abstractSerum Prostate Specific Antigen (PSA) is an established tumor marker for prostate cancer but its “specificity” for prostatic diseases was challenged after its extra prostatic sources and its presence in female serum was detected. Various studies showed the association of Total PSA (TPSA) and Free PSA (FPSA) with breast cancer in females. The present study was conducted to evaluate the status of TPSA and FPSA as a tumor marker in breast cancer patients. 54 breast cancer cases with 36 fibroadenoma patients along with 40 controls were selected for the study. Their blood samples were analyzed for estimation of serum Testosterone, TPSA and FPSA along with routine biochemical parameters. 34 breast cancer with 20 fibroadenoma cases were reevaluated for TPSA and FPSA 6 months after tumor removal by surgery. Our observations revealed high TPSA in the patient group compared to controls and raised FPSA specifically in breast cancer cases. FPSA was also found to be the predominant molecular form in breast cancer cases. A significant positive association was documented between serum Testosterone and PSA level in the study group. Both the parameters registered a significant decline after surgery. On statistical analysis TPSA and FPSA were found to possess high specificity for breast cancer cases but were deficient in the desired sensitivity to be considered as an ideal tumor marker.en_US
dc.identifier.citationDash Prakruti, Mohapatra Prakash Chandra, Mangaraj Manaswini. Evaluation of Serum Prostate Specific Antigens in Breast Cancer. Indian Medical Gazette. 2014 Nov ; 148 (11): 411-418.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157679
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ice/t14/i11/icet14i11p411.pdfen_US
dc.subjectbreast canceren_US
dc.subjecttotal PSAen_US
dc.subjectfree PSAen_US
dc.subjecttumor markeren_US
dc.subjectsensitivityen_US
dc.subjectspecificityen_US
dc.subject.meshBreast Neoplasms --diagnosis
dc.subject.meshBreast Neoplasms --surgery
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshProstate-Specific Antigen --analysis
dc.subject.meshProstate-Specific Antigen --blood
dc.subject.meshSensitivity and Specificity
dc.subject.meshTumor Markers, Biological
dc.titleEvaluation of Serum Prostate Specific Antigens in Breast Cancer.en_US
dc.typeArticleen_US
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