Study of Acetyl Cholinesterase, Butyryl Cholinestrase and β - Glucuronidase in Organophosphorus Poisoning.
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Date
2014-02
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Abstract
Organophosphorus poisoning is common problem
throughout the world. It occurs due to accidental exposure;
suicidal and homicidal attempt. Many deaths occur within
hours of ingestion of organophosphorus compounds like
pesticides. For its prevention, speedy diagnosis and prompt
treatment is required; which requires sensitive marker/s.
The aim of this study was to find such marker/s. In this
regard, activities of Acetylcholinesterase,
Butyrylcholinesterase and β-glucuronidase were estimated
in 80 samples including 40 controls and 40
organophosphorus poisoning cases (mild = 07, moderate
= 19 and severe = 14). Results indicated that activities of
Acetylcholinesterase and Butyrylcholinestrase decrease in
mild, moderate and severe Organophosphorus poisoning
in proportionate manner whereas, β-glucuronidase activity
increases as severity of Organophosphorus poisoning
progresses. Thus, all the three enzymes showed alterations
in their activities however, the degree of change in activity
was maximum in case of Acetylcholinesterase. Thus,
Acetylcholinesterase activity is the most sensitive marker
amongst three enzymes in Organophosphorus poisoning.
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Dhotre Shilpa N, Joshi Nitin G, Katkam Raghavendra V, Deshpande Kishor H. Study of Acetyl Cholinesterase, Butyryl Cholinestrase and β - Glucuronidase in Organophosphorus Poisoning. Indian Medical Gazette. 2014 Feb ; 148 (2): 51-57.