Study of Acetyl Cholinesterase, Butyryl Cholinestrase and β - Glucuronidase in Organophosphorus Poisoning.

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dc.contributor.authorDhotre, Shilpa N
dc.contributor.authorJoshi, Nitin G
dc.contributor.authorKatkam, Raghavendra V
dc.contributor.authorDeshpande, Kishor H
dc.date.accessioned2015-04-18T06:10:45Z
dc.date.available2015-04-18T06:10:45Z
dc.date.issued2014-02
dc.description.abstractOrganophosphorus poisoning is common problem throughout the world. It occurs due to accidental exposure; suicidal and homicidal attempt. Many deaths occur within hours of ingestion of organophosphorus compounds like pesticides. For its prevention, speedy diagnosis and prompt treatment is required; which requires sensitive marker/s. The aim of this study was to find such marker/s. In this regard, activities of Acetylcholinesterase, Butyrylcholinesterase and β-glucuronidase were estimated in 80 samples including 40 controls and 40 organophosphorus poisoning cases (mild = 07, moderate = 19 and severe = 14). Results indicated that activities of Acetylcholinesterase and Butyrylcholinestrase decrease in mild, moderate and severe Organophosphorus poisoning in proportionate manner whereas, β-glucuronidase activity increases as severity of Organophosphorus poisoning progresses. Thus, all the three enzymes showed alterations in their activities however, the degree of change in activity was maximum in case of Acetylcholinesterase. Thus, Acetylcholinesterase activity is the most sensitive marker amongst three enzymes in Organophosphorus poisoning.en_US
dc.identifier.citationDhotre Shilpa N, Joshi Nitin G, Katkam Raghavendra V, Deshpande Kishor H. Study of Acetyl Cholinesterase, Butyryl Cholinestrase and β - Glucuronidase in Organophosphorus Poisoning. Indian Medical Gazette. 2014 Feb ; 148 (2): 51-57.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157585
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ice/t14/i2/icet14i2p51.pdfen_US
dc.subject.meshAcetylcholinesterase --metabolism
dc.subject.meshButyrylcholinesterase --metabolism
dc.subject.meshGlucuronidase --metabolism
dc.subject.meshHumans
dc.subject.meshOrganophosphate Poisoning --enzymology
dc.subject.meshOrganophosphate Poisoning --epidemiology
dc.subject.meshOrganophosphate Poisoning --metabolism
dc.titleStudy of Acetyl Cholinesterase, Butyryl Cholinestrase and β - Glucuronidase in Organophosphorus Poisoning.en_US
dc.typeArticleen_US
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