Concurrent Low Dose Carboplatin with Radiotherapy Versus Radiotherapy alone in Management of Locally Advanced Head and Neck Cancer Patients.
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Date
2012-07
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Abstract
A prospective study was performed to evaluate the
efficacy and safety of concurrent chemotherapy with single
agent low dose Carboplatin and radiotherapy on survival,
functional and quality of life outcomes in locally advanced
head and neck cancer patients. Material and Methods :
Sixty inoperable, previously untreated locally advanced head
and neck cancer patients were planned to be treated with
radical radiotherapy 66 Gy with concurrent single agent
chemotherapy with low dose Carboplatin 150 mg IV weekly
up to 6.3 weeks (Group A) and conventional radical
radiotherapy alone (Group B). Results : After completion
of therapy in Group A complete response was observed in
19/30 (63%) patient and in control group B in 10/30
(33%).Grade II mucosal toxicities were observed in 40%
of cases and 33 % of cases in study and control group
respectively. Conclusion : Concomitant single agent chemo
radiotherapy with low dose Carboplatin could be a better
choice in advanced stage of Head and Neck carcinoma in
terms of survival, acceptable toxicities together with
enhanced response and quality of life.
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Keywords
head and neck malignancies, concurrent chemotherapy, carboplatin, radio sensitizer
Citation
Kaur Paramjeet, Singh Gajender, Chauhan Ashok. Concurrent Low Dose Carboplatin with Radiotherapy Versus Radiotherapy alone in Management of Locally Advanced Head and Neck Cancer Patients. Indian Medical Gazette. 2012 Jul ; 145 (7): 274-278.