Concurrent Low Dose Carboplatin with Radiotherapy Versus Radiotherapy alone in Management of Locally Advanced Head and Neck Cancer Patients.

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dc.contributor.authorKaur, Paramjeet
dc.contributor.authorSingh, Gajender
dc.contributor.authorChauhan, Ashok
dc.date.accessioned2015-04-14T04:25:08Z
dc.date.available2015-04-14T04:25:08Z
dc.date.issued2012-07
dc.description.abstractA prospective study was performed to evaluate the efficacy and safety of concurrent chemotherapy with single agent low dose Carboplatin and radiotherapy on survival, functional and quality of life outcomes in locally advanced head and neck cancer patients. Material and Methods : Sixty inoperable, previously untreated locally advanced head and neck cancer patients were planned to be treated with radical radiotherapy 66 Gy with concurrent single agent chemotherapy with low dose Carboplatin 150 mg IV weekly up to 6.3 weeks (Group A) and conventional radical radiotherapy alone (Group B). Results : After completion of therapy in Group A complete response was observed in 19/30 (63%) patient and in control group B in 10/30 (33%).Grade II mucosal toxicities were observed in 40% of cases and 33 % of cases in study and control group respectively. Conclusion : Concomitant single agent chemo radiotherapy with low dose Carboplatin could be a better choice in advanced stage of Head and Neck carcinoma in terms of survival, acceptable toxicities together with enhanced response and quality of life.en_US
dc.identifier.citationKaur Paramjeet, Singh Gajender, Chauhan Ashok. Concurrent Low Dose Carboplatin with Radiotherapy Versus Radiotherapy alone in Management of Locally Advanced Head and Neck Cancer Patients. Indian Medical Gazette. 2012 Jul ; 145 (7): 274-278.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157425
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ice/t12/i7/icet12i7p274.pdfen_US
dc.subjecthead and neck malignanciesen_US
dc.subjectconcurrent chemotherapyen_US
dc.subjectcarboplatinen_US
dc.subjectradio sensitizeren_US
dc.subject.meshCarboplatin --administration & dosage
dc.subject.meshCarboplatin --therapeutic use
dc.subject.meshCombined Modality Therapy
dc.subject.meshFemale
dc.subject.meshHead and Neck Neoplasms --drug therapy
dc.subject.meshHead and Neck Neoplasms --radiotherapy
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRadiotherapy
dc.subject.meshRadiotherapy Dosage
dc.titleConcurrent Low Dose Carboplatin with Radiotherapy Versus Radiotherapy alone in Management of Locally Advanced Head and Neck Cancer Patients.en_US
dc.typeArticleen_US
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