Challenges of Ionizing Radiation in Tumor Treatment and Role of Angiogenesis.
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Date
2014-12
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Abstract
Ionizing radiation is a non-specific, but most widely used therapeutic method for cancer treatment. However, a minor fraction of tumor cell population manages to survive after radiation. Radiation efficacy depends on adequate oxygen supply. Rapid growing tumors cause hypoxia that upregulates many pro-survival pathways. At clinical doses, radiation activates inflammatory pathways and causes oxidative stress that plays a positive role during angiogenesis. Selective targeting of signaling mechanisms may radiosensitize tumors.
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Keywords
Angiogenesis, Hypoxia, Ionizing radiation, Signaling mechanism, VEGF
Citation
Das Subir Kumar, Challenges of Ionizing Radiation in Tumor Treatment and Role of Angiogenesis. Indian Journal of Biochemistry & Biophysics. 2014 Dec ; 51 (6): 527-530.