Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells.
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Date
2014-12
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Abstract
Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions. Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of colorectal cancers (CRC) by allowing the cells to produce excess inflammatory eicosanoids, such as prostaglandins, thromboxanes and leukotrienes. Over the years, efforts have been made to understand the lipid remodeling pathways and to design anti-cancer drugs targeting the enzymes of eicosanoid biosynthesis. Here, we discuss the recent progress in phospholipid remodeling and eicosanoid biosynthesis in CRC.
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Keywords
Colon cancer, Arachidonic acid, Lipid remodeling, Cyclooxygenase, Lipooxygenase, Prostaglandins, Leukotrienes
Citation
Das Siddhartha, Martinez Leobarda Robles, Ray Suparna. Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells. Indian Journal of Biochemistry & Biophysics. 2014 Dec ; 51(6): 512-519.