Kinetic modelling of coupled transport across biological membranes.
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Date
2014-04
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Abstract
In this report, we have modelled a secondary active co-transporter (symport and antiport), based on the classical kinetics model. Michaelis-Menten model of enzyme kinetics for a single substrate, single intermediate enzyme catalyzed reaction was proposed more than a hundred years ago. However, no single model for the kinetics of co-transport of molecules across a membrane is available in the literature. We have made several simplifying assumptions and have followed the basic Michaelis-Menten approach. The results have been simulated using GNU Octave. The results will be useful in general kinetic simulations and modelling.
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Keywords
Antiport, Symport, Simulation, Octave, Michaelis-Menten kinetics
Citation
Korla Kalyani, Mitra Chanchal K. Kinetic modelling of coupled transport across biological membranes. Indian Journal of Biochemistry & Biophysics. 2014 Apr; 51(2): 93-99.