Protective effect of Dillenia indica L. on acetic acid induced colitis in mice.
Loading...
Date
2014-09
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The inflammatory bowel disease (IBD) is an idiopathic, immune mediated and chronic inflammation of the intestine. The study aimed to elucidate the ameliorative effect of methanolic extract of Dillenia indica (DIME), hexane fraction (HFDI) and chloroform fraction (CFDI) of Dillenia indica in acetic acid induced experimental colitis in mice. Macroscopic score, colon weight, colonic catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), myeloperoxidase (MPO), malondialdehyde (MDA), tumor necrosis factor (TNF-α), and histological changes were recorded after the treatment regimen of 7 days. Intra-rectal instillation of acetic acid caused enhanced macroscopic score, colon weight, colonic MPO, MDA, and TNF-α level. It caused significant decreased level of CAT, SOD and GSH. DIME (800 mg/kg), HFDI (200 mg/kg) and CFDI (200 mg/kg) treatment exhibited significant effect in lowering macroscopic score, colon weight, MPO, MDA, TNF-α levels and elevation of CAT, GSH and SOD levels. The results suggest that D. indica has ameliorating effects on experimental colitis by inhibiting the proinflammatory mediators like TNF-α production.
Description
Keywords
Acetic acid, Anti-inflammatory, Antioxidant, Dillenia indica, Dillenia indica, Ulcerative colitis
Citation
Somani S J, Badgujar L B, Sutariya B K, Saraf M N. Protective effect of Dillenia indica L. on acetic acid induced colitis in mice. Indian Journal of Experimental Biology. 2014 Sept; 52(9): 876-881.