Protective effect of Dillenia indica L. on acetic acid induced colitis in mice.

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dc.contributor.authorSomani, S J
dc.contributor.authorBadgujar, L B
dc.contributor.authorSutariya, B K
dc.contributor.authorSaraf, M N
dc.date.accessioned2014-12-12T04:51:57Z
dc.date.available2014-12-12T04:51:57Z
dc.date.issued2014-09
dc.description.abstractThe inflammatory bowel disease (IBD) is an idiopathic, immune mediated and chronic inflammation of the intestine. The study aimed to elucidate the ameliorative effect of methanolic extract of Dillenia indica (DIME), hexane fraction (HFDI) and chloroform fraction (CFDI) of Dillenia indica in acetic acid induced experimental colitis in mice. Macroscopic score, colon weight, colonic catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), myeloperoxidase (MPO), malondialdehyde (MDA), tumor necrosis factor (TNF-α), and histological changes were recorded after the treatment regimen of 7 days. Intra-rectal instillation of acetic acid caused enhanced macroscopic score, colon weight, colonic MPO, MDA, and TNF-α level. It caused significant decreased level of CAT, SOD and GSH. DIME (800 mg/kg), HFDI (200 mg/kg) and CFDI (200 mg/kg) treatment exhibited significant effect in lowering macroscopic score, colon weight, MPO, MDA, TNF-α levels and elevation of CAT, GSH and SOD levels. The results suggest that D. indica has ameliorating effects on experimental colitis by inhibiting the proinflammatory mediators like TNF-α production.en_US
dc.identifier.citationSomani S J, Badgujar L B, Sutariya B K, Saraf M N. Protective effect of Dillenia indica L. on acetic acid induced colitis in mice. Indian Journal of Experimental Biology. 2014 Sept; 52(9): 876-881.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153771
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/29333en_US
dc.subjectAcetic aciden_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAntioxidanten_US
dc.subjectDillenia indicaen_US
dc.subjectDillenia indicaen_US
dc.subjectUlcerative colitisen_US
dc.subject.meshAcetic Acid
dc.subject.meshAnimals
dc.subject.meshColitis --chemically induced
dc.subject.meshColitis --drug therapy
dc.subject.meshColon --drug effects
dc.subject.meshColon --pathology
dc.subject.meshDilleniaceae --chemistry
dc.subject.meshFemale
dc.subject.meshMice
dc.subject.meshOrgan Size --drug effects
dc.subject.meshPlant Extracts --chemistry
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshProtective Agents --chemistry
dc.subject.meshProtective Agents --pharmacology
dc.titleProtective effect of Dillenia indica L. on acetic acid induced colitis in mice.en_US
dc.typeArticleen_US
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