Hypertrophic cardiomyopathy: Part 1 - Introduction, pathology and pathophysiology.
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Date
2014-04
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Abstract
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease with many
genotype and phenotype variations. Earlier terminologies, hypertrophic obstructive cardiomyopathy and
idiopathic hypertrophic sub‑aortic stenosis are no longer used to describe this entity. Patients present with
or without left ventricular outflow tract (LVOT) obstruction. Resting or provocative LVOT obstruction occurs
in 70% of patients and is the most common cause of heart failure. The pathology and pathophysiology of
HCM includes hypertrophy of the left ventricle with or without right ventricular hypertrophy, systolic anterior
motion of mitral valve, dynamic and mechanical LVOT obstruction, mitral regurgitation, diastolic dysfunction,
myocardial ischemia, and fibrosis. Thorough understanding of pathology and pathophysiology is important
for anesthetic and surgical management.
Description
Keywords
Heart failure, Hypertrophic cardiomyopathy, Left ventricular outflow obstruction, Mitral regurgitation, Systolic anterior motion
Citation
Varma Praveen Kerala, Neema Praveen Kumar. Hypertrophic cardiomyopathy: Part 1 - Introduction, pathology and pathophysiology. Annals of Cardiac Anaesthesia. 2014 Apr; 17(2): 118-124.