Polymeric nanoparticle formulation of Octapeptide (NP-OP): In vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn.
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Date
2013-11
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Abstract
yielded an average particle size of 120 nm with 70% encapsulation-efficiency. In vitro release profile of NP-OP showed sustained release of OP for 21 days. In vivo anti-fertility studies were conducted in marmosets. Results indicated that control animals conceived in the same cycle while two of three treated animals failed to conceive in treatment cycle. The in vivo studies thus corroborate with in vitro release of OP, demonstrating its anti-fertility activity in 66% of animals.
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Keywords
Anti-fertility, Encapsulation efficiency, Follicle stimulating hormone binding-inhibitor, Polylactide, Synthetic peptides, TEM
Citation
Nandedkar T D, Sagvekar P, Thakur B, Navlakhe R, Chitnis S, Mahale S D, D’Souza S, Patel K D, Vavia P R. Polymeric nanoparticle formulation of Octapeptide (NP-OP): In vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn. Indian Journal of Experimental Biology. 2013 Dec; 51(12): 1055-1062.